Alexander Lindsay, 1st of Vane, was the youngest son of Sir David Lindsay of Edzell and had a novodamus charter of the lands of Vane from his nephew, David, Earl of Crawford, on 5 May 1550. He was present at the retour of Patrick, Lord Glamis, as heir to his father, John, Lord Glamis, on 31 March 1579 and also at the retour of George Multrae of Markinch as heir to his father, John Multrae of Markinch, on 2 May 1581.
He d. in 1583/4, having m. firstly, after March 1533 and by 31 August 1547, to Elizabeth, natural daughter of David Bethune, Archbishop of St. Andrews, when they had a charter for the half lands of Scryne which belonged to her by the terms of an agreement of 30 March 1533, between her mother, Marion Ogilvy, and uncle, James Bethune of Melgund, on the one part, and Robert Maule of Panmure on the other, for the proposed marriage between Elizabeth and Thomas Maule, Robert’s son and heir. By her he was father of,
- David Lindsay, 2nd of Vane, (see below).
- Patrick Lindsay, who is named with his brother, David Lindsay of Vane, in a discharge by them to their step-mother, Alison Charteris, dated 14 December 1584, and in which they are styled sons of the deceased Alexander Lindsay of Vane.
He m. secondly, to Alison, sister and coheir of John Charteris of Cuthilgurdy, (c/m 2 May 1574. She was widow of Thomas Fotheringham of Powrie, by whom she had issue), and had no apparent issue.
David Lindsay, 2nd of Vane, is styled eldest son and heir to Alexander Lindsay of Vane when witness, with his father, to a Sasine in favour of Margaret Lindsay, relict of Richard Stewart, Lord Innermeath, for her terce of the lands of Redcastle, dated 8 June 1580. He succeeded on his father’s death and had Sasine for the lands of Vane as heir to him on 10 March 1584/85.
He m. Margaret, daughter of John Stewart, 4th Lord Innermeath, (she d. before 6 February 1602), who is styled his wife in a complaint raised against Andrew Gray of Dunninald on 28 November 1581, and d. about 1610. He was father of,
- David Lindsay, 3rd of Vane, (see below).
- Hary Lindsay, who, in 1619, is styled uncle to Alexander Lindsay, sometime of Vane, when included in a list of those persons still remaining unrelaxed from previous hornings issued against them.
- Mr. Patrick Lindsay, is styled brother to the late David Lindsay of Vane when he was complained of by Patrick Lindsay of Barnyards in 1620 for having been in a party led by Sir Harie Lindsay of Carreston that came to his house in Glenqueich and “laid violent hands on his person, tooke him furth of his said house, and caryit him captive to the place of Fynnevin.”
- Alison Lindsay, m. John Allardice, fiar of that Ilk, (c/m 14 May 1593).
David Lindsay, 3rd of Vane, succeeded his father and was served heir to his grandfather, Alexander Lindsay of Vane, in the lands of Kirkton of Fern on 12 November 1614. He m. Barbara, daughter of Andrew Wemyss of Myrecairney, (c/m 14 October 1603), and d. before 5 July 1617 having had issue,
Alexander Lindsay, 4th of Vane, succeeded his father and was served heir to his grandfather, David Lindsay of Vane, in the lands of Vane on 5 July 1617. He appears to have been greatly encumbered by debt and is complained of in 1619 for being unrelaxed from previous letters of horning brought against him. He was discharged by his nephew, John Allardice, of that Ilk, on 27 December 1622, for certain debts outstanding by the terms of the marriage contract between he and his aunt, Alison Lindsay, and appears to have either disponed his estate soon afterwards or else had it apprised by creditors.
 GD52/1047. See also: RMS 1547-1580. No. 453.
 Ex. Rolls. Vol. XXI. P. 507. As at March 1584/85, his lands are said to have been lapsed for a period of about one year.
 GD45/16/575. Her marriage to Maule was not completed.
 Ex. Rolls. Vol. XXI. P. 507.
 Reg. Privy Council – 1619.
 Reg. Privy Council – 1620.
 Reg. Privy Council – 1619.
 The remains of Vane Castle can still be seen and judging by the lack of alterations to the fortifications within its structure, it appears to have ceased to have been occupied in the first half of the 17th century.